Question ID - 10437 | SaraNextGen Top Answer
Sickle-cell anaemia is an autosomal linked recessive trait can be transmitted from parents to the offspring when both the partners are carrier for all the genes or heterozygous. The disease is controlled by a single pair of allele, 
and 
. Identify X, Y and Z
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a)
GTG GAC Val (GUG)
b)
CAC CTC val (GUG)
c)
GTA GAG val (GUG)
d)
GTC GAC val (GUG)
Sickle-cell anaemia is an autosomal linked recessive trait can be transmitted from parents to the offspring when both the partners are carrier for all the genes or heterozygous. The disease is controlled by a single pair of allele, and . Identify X, Y and Z
a)
GTG GAC Val (GUG)
b)
CAC CTC val (GUG)
c)
GTA GAG val (GUG)
d)
GTC GAC val (GUG)
|
(a) In sickle-cell anaemia only one nucleotide substitution takes place from T to A. Genetic or chromosomal symbol used for person who is having sickle-cell anaemia Sickle-cell Anaemia (i) It is an autosome-linked recessive trait (ii) The disease is controlled by a single pair of allele (iii) Only the homozygous individuals for (iv) The heterozygous individuals are carriers ( (v) Due to point mutation, glutamic acid (Glu) is replaced by valine (Val) at the sixth position of (vi) A single base substitution at sixth codon of the beta globulin gene from GAG to GUG. GAG code for glutamic acid and GUG code for valine.
|
.
and 
, i.e., 
show the diseased phenotype
)
-globin chain of haemoglobin molecule
behaves as normal haemoglobin except under the oxygen stress where erythrocytes lose their circular shape and become sickle-shaped. As a result, the cells cannot pass through narrow capillaries. Blood capillaries are clogged and thus, affect blood supply to different organsAnswer Link
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